Changes in tight junctions of thyroid epithelium with changes in thyroid activity
نویسندگان
چکیده
The morphology of the tight junction of rat thyroid epithelium was examined in freeze-fractured material fixed in glutaraldehyde and briefly glycerinated. In normal thyroids the overall appearance of this junctional specialization resembled that of other cell types in many respects. Short-term changes in thyroid activity and hypophysectomy for 3 wk did not obviously affect the appearance of tight junctions. Feeding of the goitrogen, thiouracil, which stimulates secretion of thyroid-stimulating hormone, resulted in the appearance of some very narrow and some very wide, tight junctions or sometimes junctions with both wide and narrow regions within the same cell.
منابع مشابه
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عنوان ژورنال:
- The Journal of Cell Biology
دوره 66 شماره
صفحات -
تاریخ انتشار 1975